|
|
NADP+ + acetoacetate + coenzyme_M <=> 2-oxopropyl-CoM + NADPH + CO2
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
M
|
|
BRENDA:
BR29460
KEGG:
R05713
MetaCyc:
1.8.1.5-RXN
|
|
|
|
2-(R)-hydroxypropyl-CoM <=> coenzyme_M + (R)-1,2-epoxypropane
|
4.4.1.23
2-hydroxypropyl-CoM lyase
|
–
|
M
|
|
BRENDA:
BR36963
KEGG:
R05761
MetaCyc:
4.2.99.19-RXN
|
|
|
|
coenzyme_B + coenzyme_M + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
BMK
|
|
BRENDA:
BR47628
KEGG:
R04540
MetaCyc:
1.8.98.1-RXN
|
|
|
|
coenzyme_M + 5-Methyl-5,6,7,8-tetrahydromethanopterin + Na+ <=> methyl-CoM + 5,6,7,8-tetrahydromethanopterin + Na+
|
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
|
BM
|
|
BRENDA:
BR47637
MetaCyc:
2.1.1.86-RXN
|
|
|
|
2-(S)-hydroxypropyl-CoM <=> coenzyme_M + (S)-1,2-epoxypropane
|
4.4.1.23
2-hydroxypropyl-CoM lyase
|
–
|
M
|
|
BRENDA:
BR49522
KEGG:
R05762
MetaCyc:
RXN-8805
|
|
|
|
a_[methyl-Co(III)_methanol-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_methanol-specific_corrinoid_protein] + H+
|
2.1.1.246
[methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
M
|
|
BRENDA:
BR50040
MetaCyc:
RXN-8096
|
|
|
|
a_[methyl-Co(III)_methylamine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_methylamine-specific_corrinoid_protein] + H+
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
M
|
|
BRENDA:
BR50041
MetaCyc:
RXN-8099
|
|
|
|
methanethiol + coenzyme_M <=> methyl-CoM + Sulfide + H+
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
K
|
|
BRENDA:
BR50045
KEGG:
R09997
MetaCyc:
RXN-13229
|
|
|
|
a_[methyl-Co(III)_tetramethylammonium-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_tetramethylammonium-specific_corrinoid_protein] + H+
|
2.1.1.253
[methyl-Co(III) tetramethylammonium-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
M
|
|
BRENDA:
BR50049
MetaCyc:
RXN-8133
|
|
|
|
fumarate + coenzyme_M + coenzyme_B <=> succinate + CoM-S-S-CoB
|
1.3.4.1
fumarate reductase (CoM/CoB)
|
–
|
K
|
|
BRENDA:
BR50936
KEGG:
R10660
MetaCyc:
RXN-15295
|
|
|
|
coenzyme_B + coenzyme_M + oxidized_ferredoxin <=> CoM-S-S-CoB + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.8.7.3
ferredoxin:CoB-CoM heterodisulfide reductase
|
–
|
MK
|
|
BRENDA:
BR52239
KEGG:
R11931
MetaCyc:
RXN-18520
|
|
|
|
coenzyme_B + coenzyme_M + coenzyme_F420 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + reduced_coenzyme_F420 + oxidized_ferredoxin
|
1.8.98.4
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
BMK
|
|
BRENDA:
BR52240
KEGG:
R11928
MetaCyc:
RXN-18528
|
|
|
|
coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + H2 + oxidized_ferredoxin
|
1.8.98.5
H2:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
BMK
|
|
BRENDA:
BR52241
KEGG:
R11943
MetaCyc:
RXN-18521
|
|
|
|
coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 <=> CoM-S-S-CoB + formate + oxidized_ferredoxin
|
1.8.98.6
formate:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
BMK
|
|
BRENDA:
BR52242
KEGG:
R11944
MetaCyc:
RXN-18529
|
|
|
|
2-hydroxypropyl-CoM <=> coenzyme_M + propylene_oxide
|
4.4.1.23
2-hydroxypropyl-CoM lyase
|
–
|
|
|
BRENDA:
BS260014
MetaCyc:
RXN-17584
|
|
|
|
2-hydroxyethyl-CoM <=> coenzyme_M + Epoxyethane
|
4.4.1.23
2-hydroxypropyl-CoM lyase
|
–
|
MK
|
|
BRENDA:
BS368439
KEGG:
R11897
MetaCyc:
RXN-17582
|
|
|
|
a_[methyl-Co(III)_dimethylamine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_dimethylamine-specific_corrinoid_protein] + H+
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
M
|
|
BRENDA:
BS417876;
BS419212
MetaCyc:
RXN-8101
|
|
|
|
a_[methyl-Co(III)_trimethylamine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_trimethylamine-specific_corrinoid_protein] + H+
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
M
|
|
BRENDA:
BS417880;
BS418129
MetaCyc:
RXN-8103
|
|
|
|
methyl-CoM + tetrahydrosarcinapterin <=> 5-methyltetrahydrosarcinapterin + coenzyme_M
|
2.1.1
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
–
|
M
|
|
BRENDA:
BS432630
MetaCyc:
MTRMBARK-RXN
|
|
|
|
5-Methyl-5,6,7,8-tetrahydromethanopterin + coenzyme_M <=> 5,6,7,8-tetrahydromethanopterin + methyl-CoM
|
2.1.1.86
tetrahydromethanopterin S-methyltransferase
|
–
|
|
|
BRENDA:
BS356061
|
|
|
|
methanol + coenzyme_M <=> methyl-CoM + H2O
|
2.1.1.246
[methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.90
methanol---corrinoid protein Co-methyltransferase
|
–
–
|
K
|
|
KEGG:
R09098
MetaCyc:
MTAMBARKMULTI-RXN
|
|
|
|
2-Chloro-2-hydroxyethyl-CoM <=> coenzyme_M + 2-chloroethylene_oxide
|
4.4.1.23
2-hydroxypropyl-CoM lyase
|
–
|
MK
|
|
KEGG:
R11899
MetaCyc:
RXN-17583
|
|
|
|
coenzyme_M + methylcobalamin <=> methyl-CoM + cob(I)alamin + H+
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
–
|
|
|
BRENDA:
BS417961
SABIO-RK:
14562
|
|
|
|
trimethylamine + coenzyme_M <=> methyl-CoM + Dimethylamine
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.250
trimethylamine---corrinoid protein Co-methyltransferase
|
–
–
|
K
|
|
KEGG:
R09124
|
|
|
|
2-sulfoacetaldehyde <=> coenzyme_M
|
not assigned
|
–
|
K
|
|
KEGG:
R09153
|
|
|
|
methylamine + coenzyme_M <=> NH3 + methyl-CoM
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.248
methylamine---corrinoid protein Co-methyltransferase
|
–
–
|
K
|
|
KEGG:
R09998
|
|
|
|
Dimethylamine + coenzyme_M <=> methyl-CoM + methylamine
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.249
dimethylamine---corrinoid protein Co-methyltransferase
|
–
–
|
K
|
|
KEGG:
R09999
|
|
|
|
coenzyme_M + methylcorrinoid_protein <=> methyl-CoM + corrinoid
|
2.1.1.246
[methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
2.1.1.253
[methyl-Co(III) tetramethylammonium-specific corrinoid protein]---coenzyme M methyltransferase
|
–
–
–
–
|
|
|
KEGG:
R10000
|
|
|
|
sulfoethylcysteine + H2O <=> NH3 + coenzyme_M + pyruvate
|
not assigned
|
–
|
M
|
|
MetaCyc:
R234-RXN
|
|
|
|
malonate + coenzyme_M + NADP+ <=> 2-carboxyethyl-CoM + NADPH + CO2
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
M
|
|
MetaCyc:
RXN-17590
|
|
|
|
[methyl-Co(III)_glycine_betaine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + [Co(I)_glycine_betaine-specific_corrinoid_protein] + H+
|
2.1.1.hh
|
–
|
M
|
|
MetaCyc:
RXN-21057
|
|
|
|
[methyl-Co(III)_methanethiol-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + [Co(I)_methanethiol-specific_corrinoid_protein] + H+
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-8126
|
|
|
|
Dimethylsulfide + coenzyme_M <=> methyl-CoM + methanethiol
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BS417933
|
|
|
|
insulin_disulfide + coenzyme_M <=> Insulin_dithiol + oxidized_coenzyme_M
|
1.8.1.B5
|
–
|
|
|
BRENDA:
BS433844
|
|
|
|
coenzyme_M_disulfide + 5,5''-dithiobis(2-nitrobenzoic_acid) <=> 2 coenzyme_M + 5-thio-2-nitrobenzoate
|
1.8.1.8
protein-disulfide reductase
|
–
|
|
|
BRENDA:
BS441205
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + reduced_ferredoxin <=> coenzyme_B + coenzyme_M + Ferredoxin
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS440196
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + 2-hydroxyphenazine <=> coenzyme_B + coenzyme_M + 2-hydroxyphenazine
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373894
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydro-2-hydroxyphenazine <=> coenzyme_B + coenzyme_M
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373891
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_cytochrome_b <=> coenzyme_B + coenzyme_M + oxidized_cytochrome_b
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS371050
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_phenazine-1-carboxylic_acid <=> coenzyme_B + coenzyme_M + phenazine-1-carboxylic_acid
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373903
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_2-bromophenazine <=> coenzyme_B + coenzyme_M + reduced_2-bromophenazine
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373893
|
|
|
|
coenzyme_B + coenzyme_M + methanophenazine <=> N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS356009
|
|
|
|
3-(methylthio)propanoate + coenzyme_M <=> methyl-CoM + 3-Mercaptopropionate
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BS418008
|
|
|
|
2-hydroxyethyl_methyl_sulfide + coenzyme_M <=> methyl-CoM + 3-mercapto-1-propanol
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BS418278
|
|
|
|
a_[methyl-Co(III)_methylated-thiol-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_methylated-thiol-specific_corrinoid_protein]
|
2.1.1.251
methylated-thiol---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BR50047
|
|
|
|
a_[methyl-Co(III)_monomethylamine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + a_[Co(I)_monomethylamine-specific_corrinoid_protein]
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BS417879
|
|
|
|
[methyl-Co(III)_monomethylamine-specific_corrinoid_protein] + coenzyme_M <=> methyl-CoM + [Co(I)_monomethylamine-specific_corrinoid_protein]
|
2.1.1.247
[methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
|
–
|
|
|
BRENDA:
BS419213
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + Ferredoxin + 2 H2 <=> coenzyme_B + coenzyme_M + reduced_ferredoxin2- + 2 H+
|
1.8.98.5
H2:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
|
|
BRENDA:
BS426133
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + H2 <=> coenzyme_B + coenzyme_M
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS371049
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + metronidazole + 2 H2 <=> coenzyme_B + coenzyme_M + reduced_metronidazole2- + 2 H+
|
1.8.98.5
H2:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
|
|
BRENDA:
BS426134
|
|
|
|
reduced_metronidazole + coenzyme_B + coenzyme_M + H+ <=> H2 + metronidazole + CoM-S-S-CoB
|
1.8.98.5
H2:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
|
|
BRENDA:
BS443880
|
|
|
|
coenzyme_B + coenzyme_M + reduced_ferredoxin + H+ + coenzyme_F420 <=> coenzyme_B-coenzyme_M_disulfide + Ferredoxin + H2 + reduced_coenzyme_F420
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS441202
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + reduced_methyl_viologen <=> coenzyme_B + coenzyme_M + methyl_viologen
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS441204
|
|
|
|
H2 + methyl_viologen + CoM-S-S-CoB <=> reduced_methyl_viologen + coenzyme_B + coenzyme_M + H+
|
1.8.98.5
H2:CoB-CoM heterodisulfide,ferredoxin reductase
|
–
|
|
|
BRENDA:
BS443621
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_methyl_viologen <=> coenzyme_B + coenzyme_M + methyl_viologen
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373898
|
|
|
|
methyl_viologen + coenzyme_B + coenzyme_M <=> reduced_methyl_viologen + CoM-S-S-CoB + H+
|
1.8.7.3
ferredoxin:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS443823
|
|
|
|
coenzyme_M_disulfide + GSSG <=> 2 coenzyme_M + glutathione
|
1.8.1.8
protein-disulfide reductase
|
–
|
|
|
BRENDA:
BS441206
|
|
|
|
coenzyme_B + coenzyme_M + methylene_blue <=> N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_methylene_blue
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS372746
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + reduced_benzyl_viologen <=> coenzyme_B + coenzyme_M + Oxidized_benzyl_viologen
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS441203
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_benzyl_viologen <=> coenzyme_B + coenzyme_M + Oxidized_benzyl_viologen
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS373895
|
|
|
|
insulin_disulfide + 2 coenzyme_M <=> Insulin + coenzyme_M_disulfide
|
1.8.1.8
protein-disulfide reductase
|
–
|
|
|
BRENDA:
BS441474
|
|
|
|
protein_disulfide + coenzyme_M <=> protein-dithiol + oxidized_coenzyme_M
|
1.8.1.B5
|
–
|
|
|
BRENDA:
BR51555
|
|
|
|
2-oxopropyl-CoM + NADPH + H+ <=> acetone + coenzyme_M + NADP+
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
|
|
BRENDA:
BS189486
|
|
|
|
coenzyme_B-coenzyme_M_disulfide + dihydromethanophenazine <=> coenzyme_B + coenzyme_M + methanophenazine
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS440195
|
|
|
|
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced_coenzyme_F420 <=> coenzyme_B + coenzyme_M + coenzyme_F420
|
1.8.98.1
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
|
–
|
|
|
BRENDA:
BS371047
|
|